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Article

Retinoic acid synthesis and hindbrain patterning in the mouse embryo.

Development (Cambridge, England) - 1 Jan 2000

Niederreither K, Vermot J, Schuhbaur B, Chambon P, Dollé P

Abstract excerpt

Targeted disruption of the murine retinaldehyde dehydrogenase 2 (Raldh2) gene precludes embryonic retinoic acid (RA) synthesis, leading to midgestational lethality (Niederreither, K., Subbarayan, V., Dolle, P. and Chambon, P. (1999). Nature Genet. 21, 444-448). We describe here the effects of this RA deficiency on the development of the hindbrain and associated neural crest. Morphological segmentation is impaired...

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Identifiers

PMID: 10654602
DOI: 10.1242/dev.127.1.75

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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