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Article

Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.

Development (Cambridge, England) - 4 Jan 2021

López-Delgado Alejandra C, Delgado Irene, Cadenas Vanessa, Sánchez-Cabo Fátima, Torres Miguel

Abstract excerpt

Vertebrate axial skeletal patterning is controlled by co-linear expression of Hox genes and axial level-dependent activity of HOX protein combinations. MEIS transcription factors act as co-factors of HOX proteins and profusely bind to Hox complex DNA; however, their roles in mammalian axial patterning remain unknown. Retinoic acid (RA) is known to regulate axial skeletal element identity through the...

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PMID: 33298461
DOI: 10.1242/dev.193813

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