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Article

Genetic deletion of<i>Cyp26b1</i>negatively impacts limb skeletogenesis by inhibiting chondrogenesis

1 Aug 2011

Abstract excerpt

Cyp26b1, a retinoic acid (RA)-metabolising enzyme, is expressed in the developing limb bud, and Cyp26b1(-/-) mice present with severe limb defects. These malformations might be attributable to an RA-induced patterning defect; however, recent reports suggest that RA is dispensable for limb patterning. In this study, we examined the role of endogenous retinoid signalling in skeletogenesis using Cyp26b1(-/-) mice...

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Identifiers

PMID: 21807937
DOI: 10.1242/jcs.084699

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