Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma.

The Prostate - 1 May 2010

Lubahn Jessica, Berndt Sonja I, Jin Carol H, Klim Aleksandra, Luly Jason, Wu William S, Isaacs Sarah, Wiley Kathleen, Isaacs William B, Suarez Brian K, Hayes Richard B, Kibel Adam S

Abstract excerpt

BACKGROUND: Because of the dramatically different clinical course of aggressive and indolent prostate carcinoma (PCa), markers that distinguish between these phenotypes are of critical importance. Apoptosis is an important protective mechanism for unrestrained cellular growth and metastasis. Therefore, dysfunction in this pathway is a key step in cancer progression. As such, genetic variants in apoptosis genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Apoptosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black or African American

Share to Black People

Share to Case-Control Studies

Share to Caspase 8

Share to Prostatic Neoplasms

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 20033885
DOI: 10.1002/pros.21098
PMCID: PMC3072829

Genes

CASP8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma.PMID 20033885Read ↗

Rare germline genetic variants and risk of aggressive prostate cancer.Semantic proximity Read ↗

Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP.Semantic proximity Read ↗

Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer.Semantic proximity Read ↗

Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.Semantic proximity Read ↗

Two common chromosome 8q24 variants are associated with increased risk for prostate cancer.Semantic proximity Read ↗

Impact of caspase-8 (CASP8) -652 6N del and D302H polymorphisms on prostate cancer in different ethnic groups.Semantic proximity Read ↗

Association of a common variant of the CASP8 gene with reduced risk of breast cancer.Semantic proximity Read ↗

Association Aamong Ppolymorphisms in the Aapoptosis-Rrelated NKX3-1, Caspase-3, Caspase-9, and BCL-2 Genes and Prostate Cancer Susceptibility From 9706 Cases and 12,567 Controls.Semantic proximity Read ↗

Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer.Semantic proximity Read ↗

Polymorphisms and haplotypes in caspases 8 and 9 genes and risk for prostate cancer: a case-control study in cohort of North India.Semantic proximity Read ↗

Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variants.Semantic proximity Read ↗

The role of apoptotic genetic polymorphisms in prostate cancer susceptibility in a North West Spain population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.