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Article

Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variants.

The Journal of urology - 1 Apr 2008

Larson Benjamin T, Magi-Galluzzi Cristina, Casey Graham, Plummer Sarah J, Silverman Robert, Klein Eric A

Abstract excerpt

PURPOSE: Allelic variations in the HPC1/RNASEL gene, especially the R462Q single nucleotide polymorphism, have been associated with increased susceptibility to prostate cancer. Prior studies have suggested that HPC1 or R462Q associated tumors present with more aggressive clinical features. We assessed a series of men undergoing radical prostatectomy for clinical and pathological measures of tumor aggressiveness...

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Identifiers

PMID: 18289577
DOI: 10.1016/j.juro.2007.11.078
PMCID: PMC4293030

Genes

RNASEL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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