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Article

Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias.

Circulation. Cardiovascular genetics - 1 Oct 2009

Naukkarinen Jussi, Nilsson Emma, Koistinen Heikki A, Söderlund Sanni, Lyssenko Valeriya, Vaag Allan, Poulsen Pernille, Groop Leif, Taskinen Marja-Riitta, Peltonen Leena

Abstract excerpt

BACKGROUND: The upstream transcription factor 1 (USF1) gene is associated with familial combined hyperlipidemia, the most common genetic dyslipidemia in humans, as well as with various dyslipidemic changes in numerous other studies. Typical of complex disease-associated genes, neither the explicit mutations have been described nor the functional consequences for risk allele carriers been reported at the cellular...

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PMID: 20031629
DOI: 10.1161/CIRCGENETICS.108.840421

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Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias.PMID 20031629Read ↗

USF1 and dyslipidemias: converging evidence for a functional intronic variant.Semantic proximity Read ↗

Genetic variants in the USF1 gene are associated with low-density lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.Semantic proximity Read ↗

Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians.Semantic proximity Read ↗

Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.Semantic proximity Read ↗

USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease.Semantic proximity Read ↗

Genetics of familial combined hyperlipidemiaSemantic proximity Read ↗

Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.Semantic proximity Read ↗

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).Semantic proximity Read ↗

USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study.Semantic proximity Read ↗

Upstream transcription factor 1 influences plasma lipid and metabolic traits in miceSemantic proximity Read ↗

USF1 gene variants, cardiovascular risk, and mortality in European Americans: analysis of two US cohort studies.Semantic proximity Read ↗

Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians.Semantic proximity Read ↗

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