Article
Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias.
Circulation. Cardiovascular genetics - 1 Oct 2009
Naukkarinen Jussi, Nilsson Emma, Koistinen Heikki A, Söderlund Sanni, Lyssenko Valeriya, Vaag Allan, Poulsen Pernille, Groop Leif, Taskinen Marja-Riitta, Peltonen Leena
Abstract excerpt
BACKGROUND: The upstream transcription factor 1 (USF1) gene is associated with familial combined hyperlipidemia, the most common genetic dyslipidemia in humans, as well as with various dyslipidemic changes in numerous other studies. Typical of complex disease-associated genes, neither the explicit mutations have been described nor the functional consequences for risk allele carriers been reported at the cellular...
Topics
- Adipose Tissue
- Adult
- Aged
- Cohort Studies
- Dyslipidemias
- Fats
- Female
- Gene Expression
- Humans
- Insulin
- Middle Aged