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Article

Influence of CYP3A5 and ABCB1 gene polymorphisms on calcineurin inhibitor-related neurotoxicity after hematopoietic stem cell transplantation.

Clinical transplantation - 1 Jan 2000

Yanagimachi Masakatsu, Naruto Takuya, Tanoshima Reo, Kato Hiromi, Yokosuka Tomoko, Kajiwara Ryosuke, Fujii Hisaki, Tanaka Fumiko, Goto Hiroaki, Yagihashi Tatsuhiko, Kosaki Kenjiro, Yokota Shumpei

Abstract excerpt

BACKGROUND: One severe side effect of calcineurin inhibitors (CNIs: such as cyclosporine [CsA] and tacrolimus [FK506]) is neurotoxicity. CNIs are substrates for CYP3A5 and P-glycoprotein (P-gp), encoded by ABCB1 gene. In the present study, we hypothesized that genetic variability in CYP3A5 and AB...

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Source

Identifiers

PMID: 20030680
DOI: 10.1111/j.1399-0012.2009.01181.x

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20030680-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Influence of CYP3A5 and ABCB1 gene polymorphisms on calcineurin inhibitor-related neurotoxicity after hematopoietic stem cell transplantation.PMID 20030680Read ↗

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