Article
Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene.
Transplantation - 27 Aug 2002
Yamauchi Atsushi, Ieiri Ichiro, Kataoka Yasufumi, Tanabe Mizuho, Nishizaki Takashi, Oishi Ryozo, Higuchi Shun, Otsubo Kenji, Sugimachi Keizo
Abstract excerpt
BACKGROUND: Tacrolimus is a substrate of P-glycoprotein (PGP) encoded by the multidrug resistant (MDR)1 gene (ABCB1). PGP, a multidrug efflux pump, restricts the distribution of tacrolimus in the brain. In this study, we investigate the correlation of ABCB1 gene polymorphism with tacrolimus-induced neurotoxicity in patients after liver transplantation. METHODS: The genotype of 6 patients with neurotoxic events...
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