Article
The -928 G/C and -362 G/C single-nucleotide polymorphisms in the promoter of MCP-1: Increased transcriptional activity and novel binding sites.
Cerebrovascular diseases (Basel, Switzerland) - 1 Feb 2010
Nyquist Paul, Zhang Jianhua, De Graba Thomas J
Abstract excerpt
BACKGROUND: The -928 guanine (G)/cytosine (C) and -362 G/C single-nucleotide polymorphisms (SNPs) in the proximal promoter region of the monocyte chemoattractant protein 1 gene have been associated with an increased risk for intimal medial thickness and carotid atherosclerosis, respectively. We characterized the transcriptional activity of these two SNPs in vitro and identified transcription factors that bind to...
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