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Article

Identification of polymorphisms in the human 11beta‐hydroxysteroid dehydrogenase type 2 gene promoter: functional characterization and relevance for salt sensitivity

5 Jun 2007

Abstract excerpt

ABSTRACT Reduced activity of llbeta‐hydroxysteroid dehydrogenase type 2 (11beta‐HSD2) plays a role in essential hypertension and the sensitivity of blood pressure to dietary salt. Nonconservative mutations in the coding region are extremelyrare and do not explain the variable 11beta‐HSD2 activity. We focused therefore on the 5′‐regulatory region and identified and characterized the first promoter polymorphisms....

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PMID: 17551100
DOI: 10.1096/fj.07-8140com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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