Article
PPARgamma promoter polymorphisms and acute coronary syndrome.
Atherosclerosis - 1 Jul 2009
Evangelisti L, Attanasio M, Lucarini L, Sofi F, Marcucci R, Giglioli C, Valente S, Gensini Gf, Abbate R, Pepe G
Abstract excerpt
BACKGROUND: PPARgamma (PPARg) is a nuclear transcription factor involved in the control of lipid and glucose homeostasis. Two PPARg common polymorphisms, Pro12Ala and 161C>T, have been found to be associated with cardiovascular disease. In this study, in addition to PPARg coding region, we looked for genetic variations in promoters and their association with acute coronary syndrome (ACS). METHODS: We studied 202...
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