Article
Allele-specific MMP-3 transcription under in vivo conditions.
Biochemical and biophysical research communications - 29 Sept 2006
Zhu Chaoyong, Odeberg Jacob, Hamsten Anders, Eriksson Per
Abstract excerpt
A common matrix metalloproteinases-3 (MMP-3) -1612 5A/6A promoter polymorphism is associated with risk for cardiovascular disease, rheumatoid arthritis, and other diseases. Here we used the haplotype chromatin immunoprecipitation method to study allele-specific MMP-3 expression under in vivo conditions in heterozygous THP-1 cells. Pyrosequencing was used to analyse the ratio of 5A-allele to 6A-allele after...
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