Article
Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium.
Biochimica et biophysica acta - 1 Mar 2010
Davydov Dmitri R, Sineva Elena V, Sistla Srinivas, Davydova Nadezhda Y, Frank Daniel J, Sligar Stephen G, Halpert James R
Abstract excerpt
We studied the kinetics of NADPH-dependent reduction of human CYP3A4 incorporated into Nanodiscs (CYP3A4-ND) and proteoliposomes in order to probe the effect of P450 oligomerization on its reduction. The flavin domain of cytochrome P450-BM3 (BMR) was used as a model electron donor partner. Unlike...
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