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Article

The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.

FEBS letters - 24 Oct 2005

Neeli Rajasekhar, Girvan Hazel M, Lawrence Andrew, Warren Martin J, Leys David, Scrutton Nigel S, Munro Andrew W

Abstract excerpt

In the model P450 BM3 system, the P450 is fused to its diflavin reductase partner in a single polypeptide. BM3 dimerizes in solution, but the catalytic relevance of the phenomenon was hitherto unknown. We show that BM3 fatty acid hydroxylase specific activity decreases sharply at low enzyme concentrations, consistent with separation of active dimer into inactive monomer. Reductase-dependent specific activities...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16214136
DOI: 10.1016/j.febslet.2005.09.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.PMID 16214136Read ↗

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