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Article

Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding.

International journal of molecular sciences - 11 Sept 2020

Esteves Francisco, Urban Philippe, Rueff José, Truan Gilles, Kranendonk Michel

Abstract excerpt

The activity of microsomal cytochromes P450 (CYP) is strictly dependent on the supply of electrons provided by NADPH cytochrome P450 oxidoreductase (CPR). The variant nature of the isoform-specific proximal interface of microsomal CYPs implies that the interacting interface between the two proteins is degenerated. Recently, we demonstrated that specific CPR mutations in the FMN-domain (FD) may induce a gain in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32933097
DOI: 10.3390/ijms21186669
PMCID: PMC7555755

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