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Article

Peroxidase activity stabilization of cytochrome P450(BM3) by rational analysis of intramolecular electron transfer.

Journal of inorganic biochemistry - 1 May 2013

Vidal-Limón Abraham, Águila Sergio, Ayala Marcela, Batista Cesar V, Vazquez-Duhalt Rafael

Abstract excerpt

Combined quantum mechanical and molecular mechanical (QM/MM) calculations were used to explore the electron pathway involved in the suicide inactivation of cytochrome P450BM3 from Bacillus megaterium. The suicide inactivation is a common phenomenon observed for heme peroxidases, in which the enzyme is inactivated as a result of self-oxidation mediated by highly oxidizing enzyme intermediates formed during the...

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PMID: 23425936
DOI: 10.1016/j.jinorgbio.2013.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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