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Article

Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups.

Breast cancer research and treatment - 1 Nov 2011

van den Broek Alexandra J, Broeks Annegien, Horlings Hugo M, Canisius Sander V M, Braaf Linde M, Langerød Anita, Van't Veer Laura J, Schmidt Marjanka K

Abstract excerpt

The tumor suppressor gene TP53 and its regulator MDM2 are both important players in the DNA-damage repair "TP53 response pathway". Common germline polymorphisms in these genes may affect outcome in patients with tumors characterized by additional somatic changes in the same or a related pathway. To evaluate this hypothesis, we determined the effect of the common germline TP53 R72P and MDM2 SNP309 polymorphisms on...

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Source

Identifiers

PMID: 21667122
DOI: 10.1007/s10549-011-1615-y

Genes

MDM2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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