Article
The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
British journal of cancer - 20 Oct 2009
Sinilnikova O M, Antoniou A C, Simard J, Healey S, Léoné M, Sinnett D, Spurdle A B, Beesley J, Chen X, Greene M H, Loud J T, Lejbkowicz F, Rennert G, Dishon S, Andrulis I L, Domchek S M, Nathanson K L, Manoukian S, Radice P, Konstantopoulou I, Blanco I, Laborde A L, Durán M, Osorio A, Benitez J, Hamann U, Hogervorst F B L, van Os T A M, Gille H J P, Peock S, Cook M, Luccarini C, Evans D G, Lalloo F, Eeles R, Pichert G, Davidson R, Cole T, Cook J, Paterson J, Brewer C, Hughes D J, Coupier I, Giraud S, Coulet F, Colas C, Soubrier F, Rouleau E, Bièche I, Lidereau R, Demange L, Nogues C, Lynch H T, Schmutzler R K, Versmold B, Engel C, Meindl A, Arnold N, Sutter C, Deissler H, Schaefer D, Froster U G, Aittomäki K, Nevanlinna H, McGuffog L, Easton D F, Chenevix-Trench G, Stoppa-Lyonnet D
Abstract excerpt
BACKGROUND: The TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide polymorphism (SNP) in the promoter region of MDM2 (309T>G, rs2279744) and a coding SNP of TP53 (Arg72Pro, rs1042522) have been shown to be of functional significance. METHODS: To investigate...
