Article
Association of TP53 codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients.
Breast cancer research : BCR - 1 Jan 2007
Toyama Tatsuya, Zhang Zhenhuan, Nishio Mariko, Hamaguchi Maho, Kondo Naoto, Iwase Hirotaka, Iwata Hiroji, Takahashi Satoru, Yamashita Hiroko, Fujii Yoshitaka
Abstract excerpt
INTRODUCTION: Single-nucleotide polymorphisms (SNPs) in codon 72 of the TP53 (also known as p53) gene (rs1042522) and in the promoter region of the MDM2 gene (SNP309; rs2279744) have been suggested to play roles in many cancers. We investigated whether these SNPs were associated with patient outcome and the effect of adjuvant systemic therapy. METHODS: The genotypes of TP53 codon 72 and MDM2 SNP309 were defined...
Topics
- Base Sequence
- Breast Neoplasms
- Codon
- DNA, Neoplasm
- Female