Article
HLAs and genes in Japanese patients with multiple sclerosis: evidence for increased frequencies of HLA-Cw3, HLA-DR2, and HLA-DQB1*0602.
Human immunology - 1 Oct 1992
Hao Q, Saida T, Kawakami H, Mine H, Maruya E, Inoko H, Saji H
Abstract excerpt
The distribution of HLA-A, B, C, DR and DRB1, DQB1, DPB1 alleles was studied in 60 Japanese patients with clinically definite multiple sclerosis (MS) using serologic and genomic analysis. We found significant associations with HLA-Cw3 (p = 0.002, pc = 0.012, RR = 3.2), DR2 (p = 0.007, RR = 2.6), and DQB1*0602 (p = 0.04, RR = 4.0) in Japanese patients for the first time. The combined presence of Cw3 and DR2 gave a...
Topics
- Alleles
- Base Sequence
- Follow-Up Studies
- Gene Expression
- Gene Frequency
- Genes, MHC Class I
- Genes, MHC Class II
- HLA Antigens
- HLA-A Antigens
- HLA-B Antigens
- HLA-C Antigens