Article
Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles.
Human immunology - 1 Jan 1994
Allen M, Sandberg-Wollheim M, Sjögren K, Erlich H A, Petterson U, Gyllensten U
Abstract excerpt
The association of MS with HLA class II alleles was studied by PCR-based typing of the DQA1, DQB1, DRB1, and DPB1 loci in 94 Swedish patients with relapses and remissions of the disease. The haplotype DRB1*1501-DQA1*0102-DQB1*0602 was found to be positively associated and three haplotypes were fo...
Topics
- Alleles
- DNA
- DNA Primers
- Disease Susceptibility
- Female
- Gene Frequency
- Genotype
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Histocompatibility Antigens Class II
- Humans
- Male
- Multiple Sclerosis
- Polymerase Chain Reaction
- Sweden