Article
Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles.
Human immunology - 1 Jan 1994
Allen M, Sandberg-Wollheim M, Sjögren K, Erlich H A, Petterson U, Gyllensten U
Abstract excerpt
The association of MS with HLA class II alleles was studied by PCR-based typing of the DQA1, DQB1, DRB1, and DPB1 loci in 94 Swedish patients with relapses and remissions of the disease. The haplotype DRB1*1501-DQA1*0102-DQB1*0602 was found to be positively associated and three haplotypes were found to be negatively associated with MS. Linkage disequilibrium makes it difficult to assess whether DRB1 or DQB1 plays...
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