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The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damage

6 Feb 2020

Abstract excerpt

Efficient DNA repair is critical for cell survival following exposure to DNA topoisomerase I (Top1) inhibitors camptothecin, a nature product from which the common chemotherapeutic drugs irinotecan and topotecan are derived. The camptothecin-derived agents exert their antitumor activities by specifically stabilizing the Top1-DNA covalent complexes (Top1cc) and blocking the DNA religation step. When exposed to...

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PMID: 32036211
DOI: 10.1016/j.biopha.2020.109875

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