Article
Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2010
Jørgensen Trine N, Alfaro Jennifer, Enriquez Hilda L, Jiang Chao, Loo William M, Atencio Stephanie, Bupp Melanie R Gubbels, Mailloux Christina M, Metzger Troy, Flannery Shannon, Rozzo Stephen J, Kotzin Brian L, Rosemblatt Mario, Bono María Rosa, Erickson Loren D
Abstract excerpt
Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to antinuclear Ab production. To identify gene intervals within Nba2 that control the development of autoantibody-producing B cells and to determine the cellular components...
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