Article
Characterization of reciprocal Lmb1-4 interval MRL-Faslpr and C57BL/6-Faslpr congenic mice reveals significant effects from Lmb3.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2007
Santiago-Raber Marie-Laure, Haraldsson M Katarina, Theofilopoulos Argyrios N, Kono Dwight H
Abstract excerpt
Susceptibility to severe lupus in MRL-Fas(lpr) mice requires not only the lpr mutation but also other predisposing genes. Using (MRL-Fas(lpr) x B6-Fas(lpr))F2 (where B6 represents C57BL/6) intercrosses that utilize the highly susceptible MRL and poorly susceptible B6 backgrounds, we previously ma...
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