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Article

Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2010

Escande-Beillard Nathalie, Washburn Lorraine, Zekzer Dan, Wu Zhongqi-Phyllis, Eitan Shoshy, Ivkovic Sonja, Lu Yuxin, Dang Hoa, Middleton Blake, Bilousova Tina V, Yoshimura Yoshitaka, Evans Christopher J, Joyce Sebastian, Tian Jide, Kaufman Daniel L

Abstract excerpt

Studies of mice lacking MHC class I (MHC I)-associated proteins have demonstrated a role for MHC I in neurodevelopment. A central question arising from these observations is whether neuronal recognition of MHC I has specificity for the MHC I allele product and the peptide presented. Using a well-established embryonic retina explant system, we observed that picomolar levels of a recombinant self-MHC I molecule...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20018625
DOI: 10.4049/jimmunol.0902159
PMCID: PMC2997386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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