Article

Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection

1992-01-01

Abstract

The mechanisms underlying rejection of grafted neural tissue are still being defined. Mechanisms relevant to genetically engineered cells are of current interest. To date, attention has focused on major histocompatibility complex (MHC) antigens as targets of graft rejection. Yet even when there is no MHC disparity, as when the patient's own cells are genetically altered, there is still a potential for graft rejection, directed against the novel antigens. We illustrate this in a rat model.

Full abstract shown under CC BY

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c23771ac-32f1-55e8-a0ce-228d3d3151a7
DOI: 10.1155/np.1992.240
PMCID: PMC2565169

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft RejectionDOI 10.1155/np.1992.240Read

Accept or Reject: The Role of Immune Tolerance in the Development of Stem Cell Therapies and Possible Future ApproachesSemantic proximity Read

Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting CellsSemantic proximity Read

In Vivo Imaging of Embryonic Stem Cells Reveals Patterns of Survival and Immune Rejection Following TransplantationSemantic proximity Read

Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of toleranceSemantic proximity Read

Identification and characterization of cells infiltrating the graft and aqueous humour in rat corneal allograft rejection.Semantic proximity Read

Evaluation of immunogenicity of rat ES-cell derived endothelial cells.Semantic proximity Read

Renal allograft rejection in CD4+ T cell-reconstituted athymic nude rats. The origin of CD4+ and CD8+ graft-infiltrating cells.Semantic proximity Read

Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains.Semantic proximity Read

Brief Report: Immune Microenvironment Determines the Immunogenicity of Induced Pluripotent Stem Cell DerivativesSemantic proximity Read

Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented.Semantic proximity Read

Simultaneous Diagnosis and Gene Therapy of Immuno-Rejection in Rat Allogeneic Heart Transplantation Model Using a T-Cell-Targeted Theranostic NanosystemSemantic proximity Read

Identification of Gene Markers for the Prediction of Allograft Rejection or Permanent AcceptanceSemantic proximity Read