Article
Protective influences on experimental autoimmune encephalomyelitis by MHC class I and class II alleles.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1994
Mustafa M, Vingsbo C, Olsson T, Issazadeh S, Ljungdahl A, Holmdahl R
Abstract excerpt
Experimental autoimmune encephalomyelitis (EAE) is influenced by polymorphism of the MHC. We have previously found that Lewis rats with certain MHC haplotypes are susceptible to disease induced with the myelin basic protein (MBP) peptide 63-88, whereas Lewis rats with other MHC haplotypes are resistant. Interestingly, rats with the MHC u haplotype develop an immune response to the MBP 63-88, but do not get EAE....
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Primers
- Encephalomyelitis, Autoimmune, Experimental
- Gene Expression
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Interferon-gamma