Tumour heterogeneity: principles and practical consequences.

doi:10.1007/s00428-016-1987-9

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Article

Tumour heterogeneity: principles and practical consequences.

Virchows Archiv : an international journal of pathology - 1 Oct 2016

Stanta Giorgio, Jahn Stephan Wenzel, Bonin Serena, Hoefler Gerald

Abstract excerpt

Two major reasons compel us to study tumour heterogeneity: firstly, it represents the basis of acquired therapy resistance, and secondly, it may be one of the major sources of the low level of reproducibility in clinical cancer research. The present review focuses on the heterogeneity of neoplastic disease, both within the primary tumour and between primary tumour and metastases. We discuss different levels of...

Topics

Animals
Cell Plasticity
Genetic Heterogeneity
Humans
Neoplasm Metastasis
Neoplasms
Phenotype
Reproducibility of Results

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Open in PubMed

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PMID: 27412632
DOI: 10.1007/s00428-016-1987-9

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