Article
Parental origin of sequence variants associated with complex diseases.
Nature - 17 Dec 2009
Kong Augustine, Steinthorsdottir Valgerdur, Masson Gisli, Thorleifsson Gudmar, Sulem Patrick, Besenbacher Soren, Jonasdottir Aslaug, Sigurdsson Asgeir, Kristinsson Kari Th, Jonasdottir Adalbjorg, Frigge Michael L, Gylfason Arnaldur, Olason Pall I, Gudjonsson Sigurjon A, Sverrisson Sverrir, Stacey Simon N, Sigurgeirsson Bardur, Benediktsdottir Kristrun R, Sigurdsson Helgi, Jonsson Thorvaldur, Benediktsson Rafn, Olafsson Jon H, Johannsson Oskar Th, Hreidarsson Astradur B, Sigurdsson Gunnar, Ferguson-Smith Anne C, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Effects of susceptibility variants may depend on from which parent they are inherited. Although many associations between sequence variants and human traits have been discovered through genome-wide associations, the impact of parental origin has largely been ignored. Here we show that for 38,167 Icelanders genotyped using single nucleotide polymorphism (SNP) chips, the parental origin of most alleles can be...
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