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Article

Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors.

The Journal of investigative dermatology - 1 Apr 2010

Hüffmeier Ulrike, Bergboer Judith G M, Becker Tim, Armour John A, Traupe Heiko, Estivill Xavier, Riveira-Munoz Eva, Mössner Rotraut, Reich Kristian, Kurrat Werner, Wienker Thomas F, Schalkwijk Joost, Zeeuwen Patrick L J M, Reis André

Abstract excerpt

Recently, a deletion of two late cornified envelope (LCE) genes within the epidermal differentiation complex on chromosome 1 was shown to be overrepresented in 1,426 psoriasis vulgaris (PsV) patients of European ancestry. In this study, we report a confirmation of this finding in 1,354 PsV patients and 937 control individuals of German origin. We found an allele frequency of the deletion of 70.9% in PsV patients...

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Identifiers

PMID: 20016497
DOI: 10.1038/jid.2009.385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors.PMID 20016497Read ↗

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.Semantic proximity Read ↗

Deletion of LCE3C and LCE3B genes at PSORS4 does not contribute to susceptibility to psoriatic arthritis in German patients.Semantic proximity Read ↗

Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients.Semantic proximity Read ↗

Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population.Semantic proximity Read ↗

Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families.Semantic proximity Read ↗

Deletion of LCE3C and LCE3B genes is associated with psoriasis in a northern Chinese population.Semantic proximity Read ↗

Association analysis of LCE3C-LCE3B deletion in Tunisian psoriatic population.Semantic proximity Read ↗

Mutation analysis of the LCE3B/LCE3C genes in Psoriasis.Semantic proximity Read ↗

Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis.Semantic proximity Read ↗

Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis.Semantic proximity Read ↗

Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.Semantic proximity Read ↗

New psoriasis susceptibility genes: momentum for skin-barrier disruption.Semantic proximity Read ↗

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