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Article

New psoriasis susceptibility genes: momentum for skin-barrier disruption.

The Journal of investigative dermatology - 1 May 2011

Coto Eliecer, Santos-Juanes Jorge, Coto-Segura Pablo, Alvarez Victoria

Abstract excerpt

The epidermal differentiation complex gene cluster is on chromosome region 1q21.3, where the PSORS4 locus was mapped. A common deletion of two LCE genes (LCE3C_LCE3B-del) was associated with psoriasis. Individuals homozygous for the deletion have an impaired response of the skin barrier to exogenous agents, facilitating the systemic skin inflammation characteristic of psoriasis.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21494239
DOI: 10.1038/jid.2011.14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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