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Article

Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2009

Liu Hsin-Ping, Lin Wei-Yong, Liu Shu-Hsiang, Wang Wen-Fu, Tsai Chon-Haw, Wu Bor-Tsang, Wang Chien-Kuo, Tsai Fuu-Jen

Abstract excerpt

BACKGROUND: The administration of memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has clinically improved the cognitive function of patients with Alzheimer's disease (AD), indicating that a disturbance in glutamatergic transmission might be involved in a predisposition to developing the disease. AIM: The potential association of polymorphisms in NMDA receptor subunits NR3A and NR3B, encoded by the...

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Identifiers

PMID: 20016182
DOI: 10.1159/000254757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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