Article
Association between NMDA receptor subunit 2b gene polymorphism and Alzheimer's disease in Chinese Han population in Shanghai.
Neuroscience bulletin - 1 Oct 2010
Chen Chao, Li Xia, Wang Tao, Wang Hai-Hong, Fu Yi, Zhang Lei, Xiao Shi-Fu
Abstract excerpt
OBJECTIVE: N-methyl-D-aspartate (NMDA) receptor has been indicated to be involved in the pathogenesis of Alzheimer's disease (AD). The NMDA receptor subunit 2b (NR2B) has attracted more attention due to its characteristic distribution and selective reduction in AD brain. The present study aimed to explore the association between NMDA gene polymorphism and AD. METHODS: A total of 63 AD patients and 68 normal...
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