Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population.

doi:10.1016/j.neulet.2008.10.075

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Article

Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population.

Neuroscience letters - 6 Feb 2009

Jiang Hanqiu, Jia Jianping

Abstract excerpt

N-methyl-d-aspartate (NMDA) receptor plays a crucial role in learning, memory and information processing of human brain. Its dysfunction is related to the pathogenesis of Alzheimer's disease (AD). We detected four polymorphisms of the promoter regions of the human NMDA receptor 2B (NR2B) subunit gene (GRIN2B) in 362 AD patients and 334 healthy in North Han Chinese populations, these were -200T/G (rs1019385),...

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PMID: 18983893
DOI: 10.1016/j.neulet.2008.10.075

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APOE

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