Article
Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele.
Neurology - 26 Feb 2008
Niemann S, Landers J E, Churchill M J, Hosler B, Sapp P, Speed W C, Lahn B T, Kidd K K, Brown R H, Hayashi Y
Abstract excerpt
OBJECTIVE: The GRIN3B gene encodes NR3B, a motoneuron-specific member of the NMDA type of ionotropic glutamate receptors. NR3B reduces the Ca(2+)-permeability as well as the overall current of the receptor response and may thereby protect motoneurons against glutamate-mediated excitotoxicity. We tested whether genetic dysfunction of GRIN3B is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS)....
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