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Article

C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane.

Molecular cell - 1 Nov 1999

Labrousse A M, Zappaterra M D, Rube D A, van der Bliek A M

Abstract excerpt

Little is known about the mechanism of mitochondrial division. We show here that mitochondria are disrupted by mutations in a C. elegans dynamin-related protein (DRP-1). Mutant DRP-1 causes the mitochondrial matrix to retract into large blebs that are both surrounded and connected by tubules of outer membrane. This indicates that scission of the mitochondrial outer membrane is inhibited, while scission of the...

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Identifiers

PMID: 10619028
DOI: 10.1016/s1097-2765(00)80391-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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