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Article

PI(3)P regulates mitochondrial dynamics through FGD-dependent actin organization.

The Journal of cell biology - 1 Jun 2026

Zhao Shan, Zhang Jie, Ma Tengfei, Li Jinglin, Duan Mei, Wang Xin, Li Meijiao, Yang Chonglin

Abstract excerpt

Mitochondria form highly complex and dynamic networks to maintain their homeostasis. However, the underlying mechanisms remain elusive. Here we report a PI(3)P-dependent mechanism that regulates the mitochondrial dynamics required for formation of mitochondrial networks. Using genetic screening, we reveal that mutations of Caenorhabditis elegans EXC-5/FGD lead to formation of spherical and unconnected...

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PMID: 41944820
DOI: 10.1083/jcb.202508040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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