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Article

Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation.

Pharmacogenetics and genomics - 1 Oct 2007

Mercier Cédric, Raynal Caroline, Dahan Laetitia, Ortiz Adrien, Evrard Alexandre, Dupuis Charlotte, Blesius Aurore, Duluc Muriel, Franceschini Fleur, Giacometti Sarah, Salas Sébastien, Milano Gérard, Favre Roger, Seitz Jean-François, Ciccolini Joseph

Abstract excerpt

Gemcitabine is an antimetabolite drug used in the treatment of various solid tumours, including lung, pancreatic or gynaecological cancers. Innovative combinational strategies (e.g. gemcitabine+capecitabine or gemcitabine+oxaliplatin) make gemcitabine an extensively prescribed drug now. Gemcitabine is characterized by a narrow therapeutic index, and its liver elimination depends upon a key enzymatic step, driven...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17885621
DOI: 10.1097/FPC.0b013e32825ea6e3

Genes

CDA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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