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Article

The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling.

The Journal of biological chemistry - 8 Feb 2013

Li Shi-Yang, Du Ming-Juan, Wan Ya-Juan, Lan Bei, Liu Yao-Hui, Yang Yin, Zhang Cui-Zhu, Cao Youjia

Abstract excerpt

Vav1 is a guanine nucleotide exchange factor (GEF) specifically expressed in hematopoietic cells. It consists of multiple structural domains and plays important roles in T cell activation. The other highly conserved isoforms of Vav family, Vav2 and Vav3, are ubiquitously expressed in human tissues including lymphocytes. All three Vav proteins activate Rho family small GTPases, which are involved in a variety of...

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Identifiers

PMID: 23271736
DOI: 10.1074/jbc.M112.426221
PMCID: PMC3567632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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