Article
Control of pre-T cell proliferation and differentiation by the GTPase Rac-I.
Nature immunology - 1 Oct 2000
Gomez M, Tybulewicz V, Cantrell D A
Abstract excerpt
The GTPase Rac-I has the potential for pleiotropic functions due to its ability to interact with multiple effectors. Here, activation of Rac-I is shown to potently regulate pre-T cell differentiation and proliferation at the point of T cell antigen receptor (TCR) beta selection. An activated Rac-I effector domain mutant that restricts signaling to particular actions on actin dynamics can drive pre-T cell...
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