Prognostic and Predictive Roles of KRAS Mutation in Colorectal Cancer

doi:10.3390/ijms131012153

Article

Prognostic and Predictive Roles of KRAS Mutation in Colorectal Cancer

25 Sept 2012

Abstract excerpt

The RAS gene family is among the most studied and best characterized of the known cancer-related genes. Of the three human ras isoforms, KRAS is the most frequently altered gene, with mutations occurring in 17%-25% of all cancers. In particular, approximately 30%-40% of colon cancers harbor a KRAS mutation. KRAS mutations in colon cancers have been associated with poorer survival and increased tumor...

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