Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.

doi:10.1093/jnci/dju106

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Article

Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.

Journal of the National Cancer Institute - 1 Jul 2014

Gonsalves Wilson I, Mahoney Michelle R, Sargent Daniel J, Nelson Garth D, Alberts Steven R, Sinicrope Frank A, Goldberg Richard M, Limburg Paul J, Thibodeau Stephen N, Grothey Axel, Hubbard Joleen M, Chan Emily, Nair Suresh, Berenberg Jeffrey L, McWilliams Robert R

Abstract excerpt

BACKGROUND: KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them. METHODS: Two thousand three hundred twenty-six of 3397 patients in the N0147 phase III adjuvant trial for stage III colon cancer completed a patient questionnaire. Primary tumors were assessed for KRAS and BRAF...

Topics

Adult
Aged
Aspartic Acid
Clinical Trials, Phase III as Topic
Colonic Neoplasms
DNA Mismatch Repair
Female
Glutamic Acid
Glycine
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Logistic Models

Male

Middle Aged

Molecular Epidemiology

Mutation

Neoplasm Grading

Prospective Studies

Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24925349
DOI: 10.1093/jnci/dju106
PMCID: PMC4110470

Genes

KRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24925349-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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