Article
Epidermal growth factor receptor status and Notch inhibition in non-small cell lung cancer cells.
Journal of biomedical science - 24 Oct 2015
Giannopoulou Efstathia, Nikolakopoulos Achilleas, Kotsirilou Dimitra, Lampropoulou Angeliki, Raftopoulou Sofia, Papadimitriou Evangelia, Theocharis Achilleas D, Makatsoris Thomas, Fasseas Konstantinos, Kalofonos Haralabos P
Abstract excerpt
BACKGROUND: Notch may behave as an oncogene or a tumor suppressor gene in lung cancer cells. Notch receptor undergoes cleavage by enzymes, including γ-secretase, generating the active Notch intracellular domain (NICD). The aim of the present study was to investigate the effect of DAPT, a γ-secretase inhibitor, in non-small cell lung cancer (NSCLC) cells, as well as the impact of epidermal growth factor (EGF) that...
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