Article
Alterations in Notch signaling in neoplastic lesions of the human cervix.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 1995
Zagouras P, Stifani S, Blaumueller C M, Carcangiu M L, Artavanis-Tsakonas S
Abstract excerpt
The development of cancer is a cellular process that reflects and is partly driven by alterations in cell determination. Mutations in various molecules responsible for cell determination have been identified as being oncogenic, but little is known about the involvement of normal cell fate-determining mechanisms in the oncogenic process. The Notch pathway defines an evolutionarily conserved, general cell...
Topics
- Antibodies
- Antibody Specificity
- Female
- Fluorescent Antibody Technique
- Gene Expression
- Humans
- Membrane Proteins
- Mutation
- Receptors, Cell Surface
- Receptors, Notch
- Signal Transduction