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Article

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53.

Cancer research - 1 Oct 2013

Licciulli Silvia, Avila Jacqueline L, Hanlon Linda, Troutman Scott, Cesaroni Matteo, Kota Smitha, Keith Brian, Simon M Celeste, Puré Ellen, Radtke Fred, Capobianco Anthony J, Kissil Joseph L

Abstract excerpt

The Notch pathway has been implicated in a number of malignancies with different roles that are cell- and tissue-type dependent. Notch1 is a putative oncogene in non-small cell lung cancer (NSCLC) and activation of the pathway represents a negative prognostic factor. To establish the role of Notch1 in lung adenocarcinoma, we directly assessed its requirement in Kras-induced tumorigenesis in vivo using an...

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Identifiers

PMID: 23943799
DOI: 10.1158/0008-5472.CAN-13-1384
PMCID: PMC3791518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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