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Article

Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity.

Mutation research - 3 Feb 2010

O'Konek Jessica J, Ladd Brendon, Flanagan Sheryl A, Im Mike M, Boucher Paul D, Thepsourinthone Tico S, Secrist John A, Shewach Donna S

Abstract excerpt

Nucleoside analogs are efficacious cancer chemotherapeutics due to their incorporation into tumor cell DNA. However, they exhibit vastly different antitumor efficacies, suggesting that incorporation produces divergent effects on DNA replication. Here we have evaluated the consequences of incorpor...

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Identifiers

PMID: 20004674
DOI: 10.1016/j.mrfmmm.2009.11.011
PMCID: PMC3038579

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20004674-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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