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Article

Effects of mirror-image nucleosides on DNA replication and transcription in human cells.

The Journal of biological chemistry - 1 Feb 2025

Jin Zhaoyang, Wang Yifei, Cui Shuaishuai, He Yujian, Wu Li

Abstract excerpt

Mirror-image nucleosides, as potential antiviral drugs, can inhibit virus DNA polymerase to prevent virus replication. Conversely, they may be inserted into the DNA strands during DNA replication or transcription processes, leading to mutations that affect genome stability. Accumulation of significant mutation damage in cells may result in cell aging, apoptosis, and even uncontrolled cell division. We have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39732173
DOI: 10.1016/j.jbc.2024.108139
PMCID: PMC11815684

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