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Article

DNA synthesis arrest at C4'-modified deoxyribose residues.

Biochemistry - 25 Feb 1997

Hess M T, Schwitter U, Petretta M, Giese B, Naegeli H

Abstract excerpt

Many genotoxic agents form base lesions that inhibit DNA polymerases. To study the mechanism underlying termination of DNA synthesis on defective templates, we tested the capacity of a model enzyme (Klenow fragment of Escherichia coli DNA polymerase I) to catalyze primer elongation across a series of C4' deoxyribose derivatives. A site with inverted C4' configuration or two different C4' deoxyribose adducts were...

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PMID: 9047336
DOI: 10.1021/bi961689g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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