DNA synthesis arrest at C4'-modified deoxyribose residues.

doi:10.1021/bi961689g

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Article

DNA synthesis arrest at C4'-modified deoxyribose residues.

Biochemistry - 25 Feb 1997

Hess M T, Schwitter U, Petretta M, Giese B, Naegeli H

Abstract excerpt

Many genotoxic agents form base lesions that inhibit DNA polymerases. To study the mechanism underlying termination of DNA synthesis on defective templates, we tested the capacity of a model enzyme (Klenow fragment of Escherichia coli DNA polymerase I) to catalyze primer elongation across a serie...

Topics

DNA Polymerase I
DNA Replication
Deoxyribose
Escherichia coli
Mutation

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