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Article

An experimental assessment of in silico haplotype association mapping in laboratory mice.

BMC genetics - 9 Dec 2009

Burgess-Herbert Sarah L, Tsaih Shirng-Wern, Stylianou Ioannis M, Walsh Kenneth, Cox Allison J, Paigen Beverly

Abstract excerpt

BACKGROUND: To assess the utility of haplotype association mapping (HAM) as a quantitative trait locus (QTL) discovery tool, we conducted HAM analyses for red blood cell count (RBC) and high density lipoprotein cholesterol (HDL) in mice. We then experimentally tested each HAM QTL using published crosses or new F2 intercrosses guided by the haplotype at the HAM peaks. RESULTS: The HAM for RBC, using 33 classic...

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Identifiers

PMID: 20003225
DOI: 10.1186/1471-2156-10-81
PMCID: PMC2797012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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