Article
QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits.
Behavior genetics - 1 Jan 2001
Belknap J K, Hitzemann R, Crabbe J C, Phillips T J, Buck K J, Williams R W
Abstract excerpt
Quantitative genetics and quantitative trait locus (QTL) mapping have undergone a revolution in the last decade. Progress in the next decade promises to be at least as rapid, and strategies for fine-mapping QTLs and identifying underlying genes will be radically revised. In this Commentary we address several key issues: first, we revisit a perennial challenge--how to identify individual genes and allelic variants...
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